Peptide Spotlight: MOTS-c
Meet MOTS-c: The Mitochondrial Peptide That’s Changing the Longevity Game
If you're on a journey to optimize metabolism, enhance performance, or age with strength and clarity, there’s a powerhouse peptide you need to know about: MOTS-c.
Dubbed the “exercise mimetic”, MOTS-c is rapidly gaining traction among biohackers, longevity experts, and functional medicine providers—and for good reason. It works at the mitochondrial level to turn on your body’s resilience genes and metabolic repair systems.
At The Wellness Lounge, we’re now offering MOTS-c as part of our personalized peptide stacks—tailored to your biology, goals, and current state of health.
What is MOTS-c?
MOTS-c (short for mitochondrial open reading frame of the 12S rRNA type-c) is a peptide encoded in mitochondrial DNA—not nuclear DNA—which makes it unique among peptides. Mitochondria are the energy centers of your cells, and MOTS-c helps regulate how your body uses fuel, responds to stress, and adapts to physical demands.
It acts like a cellular coach, signaling your body to become more metabolically efficient, resilient, and adaptive.
What Does MOTS-c Do?
Enhances glucose metabolism and insulin sensitivity
Promotes fat oxidation and lean muscle retention
Reduces inflammation and oxidative stress
Improves mitochondrial biogenesis (more and healthier mitochondria)
Increases endurance and exercise capacity
Boosts cognitive clarity and neuroprotection
Activates AMPK and stress resilience genes associated with longevity
Who Is MOTS-c Best For?
This peptide is an incredible option for:
Those with metabolic dysfunction (pre-diabetes, insulin resistance, weight loss resistance)
High performers and athletes seeking better endurance and faster recovery
Individuals over 40 looking to preserve lean mass and energy
Anyone with mitochondrial dysfunction, chronic fatigue, or long COVID
Biohackers and longevity-seekers wanting to optimize cellular resilience
How Is It Used?
Delivery: Subcutaneous injection, typically 5 days per week
Dose: 10–15 mg/week, often divided into 2.5–5 mg doses
Cycle: Often cycled in 4–6 week blocks followed by a rest phase
You’ll feel it most in your stamina, mood, glucose regulation, and energy stability.
What to Stack MOTS-c With
MOTS-c plays well with other peptides and therapies depending on your goals:
For Metabolic Repair + Energy:
BPC-157 – For gut health and inflammation
NAD+ IV therapy – Mitochondrial repair and longevity synergy
Berberine – Natural insulin sensitizers
For Performance & Fat Loss:
AOD-9604 – Fat-targeting peptide
CJC-1295 + Ipamorelin – Growth hormone support and muscle tone
L-Carnitine injections – Boosts fatty acid oxidation
For Brain + Mitochondrial Health:
Resveratrol or Urolithin A – Autophagy and cellular cleanup
Alpha-GPC or Lion’s Mane – Cognitive performance and neurogenesis
Why The Wellness Lounge?
We don’t do one-size-fits-all medicine. At The Wellness Lounge, we create personalized peptide stacks based on your labs, lifestyle, and long-term goals. Whether you’re looking to burn fat, recover from burnout, or sharpen your edge, we’ll design a stack that works with your biology—not against it.
Ready to Activate Your Mitochondrial Potential?
Schedule a consult at The Wellness Lounge to see if MOTS-c is right for your personalized peptide protocol. Our functional medicine team will assess your current state of health, guide your dosing strategy, and integrate other supportive therapies like NAD+, contrast therapy, IV drips, or metabolic testing to optimize your results.
Better mitochondria = better you. Let’s rebuild from the inside out.